Central nervous system immunity in relation to aging and AD

The present report discusses the immune and clearance system of central nervous (CNS) in terms its anatomical, physiological, biochemical properties. There is now a growing body evidence that progressive dysfunction meningeal lymphatic should be considered as risk factor for aging-related brain disorders. In addition, activity lymphatics may alter access CSF-carried neuromodulators to parenchyma, which also involved onset aging AD. CNS system, impairment BBB small arteries, well major protein end feet astrocytes, AQP4, are associated with or idea maximizing "waste discharge" new preventive therapeutic target neurodegenerative diseases context healthy has been accepted.